Allergy and Tissue Metabolism by W. G. Smith

By W. G. Smith

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This effect is probably unrelated to their 45 antihistaminic activity (measured pharmacologically). Indeed, so far as endothelial activation is concerned, mepyramine inhibits phagocytosis but not increased permeability, whereas promethazine inhibits 44 both. Experiments with histamine liberators and mast cell degranulating agents which might have been expected to establish unequivocally the role of mast cell histamine in the endothelial activation process met with unexpected limitations when they disclosed that compound 48/80, 44 for instance will liberate non-mast cell histamine.

The development of the increased vascular permeability coincided with the appearance in the exudate of a permeability factor having properties of a soluble globulin. The same factor was found also in rat serum together with an inhibitor substance capable of suppressing its action on vascular 56 permeability. Various factors will activate rat permeability globulin including blood clotting in the presence of blood cells, platelet extracts and incubation of serum with mitochrondrial fractions of cells.

In general, parenchymatous organs like liver (except in dog), kidney and adrenal gland are short of mast cells. Organs which have more connective tissue like testis, ovary, salivary glands, lymph nodes, spleen, pancreas and heart have a higher mast cell content. Organs like uterus, mammae, tongue, prostate, bladder and lung have a large proportion of connective tissue and high mast cell populations. Mast cells are also found in the intermuscular connective tissue of the body wall and limbs, in the connective tissue of the alimentary tract, and in 6 mesentery.

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