Advances in Parasitology, Vol. 58 by John R. Baker, Ralph Muller, David Rollinson

By John R. Baker, Ralph Muller, David Rollinson

The Advances in Parasitology sequence includes in-depth studies on present subject matters of curiosity in modern parasitology. It contains scientific reports on parasites of significant effect, corresponding to trypanosomiasis and scabies, and extra conventional parts, resembling zoology, taxonomy, and existence heritage, which form present considering and applications.

  • Series has the second one maximum ISI effect consider the parasitology staff! (4.818 in 2002)
  • Contributors are foreign specialists within the field

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Example text

THE MÈS AS HOST CELLS FOR LEISHMANIA SPP. 1. Binding and Internalization of Promastigotes and Amastigotes Both promastigotes and amastigotes can be phagocytosed by MÈs through an actin-mediated phagocytic process. Recent studies show that in most cases, phagocytosis of both L. major and L. amazonensis metacyclic promastigotes proceeds first by the engulfment of the parasite cell body followed by the progressive internalization of the flagellum. , 2002; N. Courret, S. Henri and E. Handman, unpublished observation).

Molecules were visualized using as primary antibodies the monoclonal antibody 2G9 and purified rabbit antibodies directed against the H-2M 1 cytosolic tail, respectively, and appropriate fluorochrome conjugates. The analysis of a single cell section is presented. MHC class II and H-2M molecules are co-localized in numerous endocytic compartments including a PV (arrows). Arrowheads point to the weak class II staining of the plasma membrane. n, DC nucleus. Bar, 5 mm. ) consequences for the respective capacity of these cells to present Leishmania Ags.

The last step of MHC class II intracellular trafficking leading the MHC II– peptide complexes from the PVs to the plasma membrane could be slowed down (6). Finally, the distribution of MHC–peptide complexes displayed at the MÈ cell surface could be modified in infected MÈs. It has been shown that the concentration of MHC–peptide complexes in lipid rafts of the cell surface allows more efficient presentation of Ags to T cells especially when the number of these complexes is limiting. Presence of parasite molecules like glycolipids could disrupt these membrane microdomains (7).

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