Advances in Alzheimer’s and Parkinson’s Disease: Insights, by Murat Emre (auth.), Abraham Fisher, Maurizio Memo, Fabrizio

By Murat Emre (auth.), Abraham Fisher, Maurizio Memo, Fabrizio Stocchi, Israel Hanin (eds.)

Proceedings of the seventh overseas convention on Alzheimer’s disorder and Parkinson’s sickness (ADPD), held March 9-13, 2005 in Sorrento, Italy.

The subject material of the ADPD meetings is exclusive in that it bargains not just with concerns comparable separately to Alzheimer’s disorder and Parkinson’s affliction, but in addition with the combination of those and different similar illnesses. the main updated ideas and learn findings are illustrated during this quantity, overlaying subject matters akin to immunology, neuroscience, pharmacology, genetics, molecular biology, biochemistry and the heritage, epidemiology, scientific phenomenology, prognosis, imaging, therapy ,and destiny views of Alzheimer’s and Parkinson’s Diseases.

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Mol Cell 2003;12:233–246. 3 Impaired DNA Repair Systems 21 5. Bellacosa A. Functional interactions and signaling properties of mammalian DNA mismatch repair proteins, Cell Death Differ 2001;8:1076–1092. 6. Rolig RL, McKinnon PJ. Linking DNA damage and neurodegeneration. Trends Neurosci 2000;23:417–424. 7. Brooks PJ. DNA repair in neural cells: basic science and clinical implications. Mutat Res 2002;509:93–108. 8. Marietta C, Palombo F, Gallinari P, et al. Expression of long-patch and short-patch DNA mismatch repair proteins in the embryonic and adult mammalian brain.

Pankratz N, Nichols WC, Uniacke SK, et al. Am J Hum Genet 2003;72:1053–1057. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. 47. 48. 49. 50. 51. 52. 53. 54. 55. 56. 57. 58. 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. Chapter 3 Impaired DNA Repair Systems: Generation of Mitochondrial Dysfunction and Increased Sensitivity to Excitotoxicity Simona Francisconi, Mara Codenotti, Erminia Poli, Daniela Uberti, Giulia Ferrari-Toninelli, and Maurizio Memo Introduction Preservation of genomic stability is an essential biological function, and cells engage efficient mechanisms to maintain DNA stability over time and prevent the generation and the persistence of impaired cells that may be detrimental to the organism.

Parkinson’s disease has a chronic progressive course, mainly affecting the motor system, and is responsible for severe motor impairment. The cause of the disease is still unknown, so no ‘‘cure’’ or neuroprotective treatment is yet available. On the other hand, symptomatic dopaminergic treatment is highly effective during the early phases but progressively loses its efficacy and induces motor and nonmotor complications. , postural instability, gait disturbances, cognitive impairment) that are not responsive to dopaminergic stimulation, and it has been demonstrated [3] that the most disabling long-term problems of PD are related to the occurrence of symptoms that are not alleviated by L-dopa.

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