Acetaldehyde-Related Pathology: Bridging the by Novartis Foundation(eds.)

By Novartis Foundation(eds.)

A part of the distinguished Novartis origin, this is often the 1st e-book to study the pathology linked to acetaldehyde, a recognized poisonous agent present in cigarette smoke and different toxins and derived from ingested alcohol, among different resources. within the physique, acetaldehyde impacts numerous tissues, quite the mind and liver, inflicting quite a few illnesses, together with melanoma, alcoholic liver disorder and Alzheimer’s.

Acetaldehyde-Related Pathology describes the poisonous results of acetaldehyde on the tissue and mobile degrees, reviewing enzyme biochemistry, transgenic mouse types of alcohol dehydrogenase mutants, and the cell-signalling pathways implicated in alcohol-related pathology. It explores the mechanisms of acetaldehyde-induced harm to tissues, usually a primary step in carcinogenesis, together with the oral hollow space, the human airway, and the GI tract. The booklet considers pharmacological options and coverings for decreasing oral and intestinal acetaldehyde. Acetaldehyde-Related Pathology positive aspects in-depth, round-table discussions through a world array of scientists from major laboratories all over the world concerned about reports of acetaldehyde-related pathology.

This e-book is key studying for an individual attracted to the consequences of this compound - pathologists, biochemists, toxicologists, mobile and molecular biologists.Content:

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Extra info for Acetaldehyde-Related Pathology: Bridging the Trans-Disciplinary Divide: Novartis Foundation Symposium 285

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Diabetes Res Clin Pract 66:S145–147 Narita M, Kitagawa K, Nagai Y et al 2003 Effects of aldehyde dehydrogenase genotypes on carotid atherosclerosis. Ultrasound Med Biol 29:1415–1419 Nguyen E, Picklo MJ Sr 2003 Inhibition of succinic semialdehyde dehydrogenase activity by alkenal products of lipid peroxidation. Biochim Biophys Acta 1637:107–112 Nilsson GE 1988 Studies on the role of biogenic aldehydes in brain. In: Studies on the role of biogenic aldehydes in brain. Reprocentralen HSC, Uppsala, Sweden, pp 1–47 Nordback IH, MacGowan S, Potter JJ, Cameron JL 1991 The role of acetaldehyde in the pathogenesis of acute alcoholic pancreatitis.

J Biol Chem 266:4965–4973 Crabb DW, Matsukmoto M, Chang D, You M 2004 Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. Proc Nutr Soc 63:49–63 Deitrich RA 1966 Tissue and subcellular distribution of mammalian aldehyde-oxidizing capacity. Biochem Pharmacol 15:1911–1922 Deitrich RA, Siew C 1974 Localization and function of aldehyde dehydrogenases. In: Thurman R, Yonetani T, Williamson JR, Chance B (eds). Alcohol and Aldehyde Metabolizing Systems.

5 Malondialdehyde 45 Benzaldehyde 6550 20 910 4100 500 Dihydrophytal 6 Benzaldehyde 1440 Crotonaldehyde 800 Glutaraldehyde 1700 Phytol Nonenal Km = 1 4-HNE Km = 45 Phenylacetaldehyde Propionaldehyde Propionaldehyde Benzaldehyde Fatty aldehydes C = 6–24: Km = 18–50 µM 150 1600 150 50000 Aldophosphamide 526 Propionaldehyde Benzaldehyde Propionaldehyde Benzaldehyde 4-HNE Mitochondrial matrix. Hyperprolinemia, induced by p53 Microsomal Microsomal Rat liver cytosol Rat liver cytosol Cornea Rat Liver I Rat liver I Rat liver II Rat liver II TCDD induced, tumour associated.

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